Brain Grub Chowder : Season 1 Episode 32

When Mung Daal attempts to make Chowder smarter using a food called "Brain Grub", Chowder soon becomes aware that their universe is simply an animated series, and changes it into a talk show. Mung tells him about how without Chowder, it's awful. Chowder smashes his big brain and eventually destroys the Chowder universe.